Services
Our services
We offer a comprehensive suite of services, from Target Discovery to Preclinical Studies, to support drug discovery programs at every stage. We provide biologically relevant, high-quality, actionable data, enabling you to make decisions with confidence. This helps to streamline your workflow, reduce risks, and accelerate your drug discovery timeline.
Whether you are validating a novel target, optimizing a lead compound, or conducting translational studies, we work as an extension of your team, delivering customized solutions tailored to your specific needs.
At Pelago Bioscience, we empower your drug discovery journey with robust, data-driven insights, ensuring your drug candidates progress with a strong scientific foundation. What you study in cells you will also see in patients.
Target Discovery
Optimizing Your Drug Development Outcomes
Selecting the right molecular target increases the likelihood of developing safe, effective therapeutics—while a poorly validated target can lead to costly failures in clinical development.
At Pelago Bioscience, we leverage our CETSA® technology to help you identify and validate disease-relevant targets. We provide robust biological insights that de-risk early-stage development and enhance therapeutic efficacy by assessing protein interactions in live, physiologically relevant models.
Lead Generation
Transforming Hits into High-Quality Leads
The journey from hit identification to clinical candidate selection starts with discovering the right chemical starting points—and refining them into leads with true therapeutic potential. Lead generation is where promising molecules are identified, validated, and optimized to ensure they interact effectively with disease-related targets while exhibiting strong drug-like properties.
At Pelago Bioscience, we support your discovery project at every stage of this critical phase. From custom assay development tailored to your targets to hit identification, potency ranking, and selectivity profiling, we help you build a strong foundation for success. Our proprietary CETSA technology enables you to discover hit series with the highest potential to progress into viable lead compounds.
Lead Optimization
Refinement of your best leads
Lead optimization is a pivotal stage in drug discovery, where promising compounds are refined to improve efficacy, safety, and pharmacological properties—ensuring their potential as viable drug candidates. This process relies on iterative medicinal chemistry, structure-activity relationship (SAR) studies, and thorough biological evaluations to enhance potency, selectivity, and drug-like characteristics.
At Pelago Bioscience, we support your lead optimization efforts with comprehensive compound profiling. Our services include potency ranking, mechanism of action studies, and translational research to help you understand how your compounds perform in biologically relevant systems.
By integrating CETSA® into your optimization strategy, we provide critical insights that enable informed decision-making. This allows you to de-risk your project early and confidently move forward when selecting preclinical and clinical development candidates.
Preclinical Studies
Laying the Foundation for Clinical Success
In early drug development, identifying the right starting point, determining safe dosage levels for first-in-human studies, and assessing a drug candidate’s potential toxicity is essential to ensure a smooth transition from preclinical research to clinical trials. These decisions can significantly influence the success and efficiency of later-stage development.
CETSA offers unmatched flexibility for preclinical studies and is a powerful tool for confirming target engagement in complex biological systems. By directly measuring how effectively a compound binds to its target within tissue samples from preclinical models or patient-derived materials, CETSA generates critical data that reflects real-world biological conditions.
This insight is valuable for guiding dose selection, informing biomarker development, and supporting patient stratification strategies. With a solid mechanistic understanding of target engagement at clinically relevant concentrations, you can design more focused, evidence-based clinical trials—reducing risk and maximizing the potential for success.
About CETSA
CETSA is our well recognized, best-in-class core technology used to assess cellular protein-ligand binding.