Our Lead Generation Services:
Primary Screen
Leveraging CETSA® for primary screening ensures that only compounds demonstrating genuine cellular target engagement move forward. This significantly increases the chances of identifying high-quality drug candidates, minimizes false positives, and accelerates discovery.
Key Benefits
Accelerated Discovery – Speed up your drug discovery process with efficient, high-throughput screening. y your treatment
True Target Engagement – Identify compounds with verified cellular target interaction.
Fewer False Positives – Eliminate non-specific hits early to streamline follow-up efforts.
Hit Confirmation
At Pelago Bioscience, we offer comprehensive confirmatory testing and in-depth compound evaluation. Our approach helps refine the compound design and prioritize the strongest candidates, streamlining your hit confirmation process and accelerating the path to lead optimization.
Key Benefits
Streamlined Development Path – Accelerate progression to lead optimization by eliminating weak candidates early roven success developing assays for both well-established and hard-to-drug targets
Physiologically Relevant Validation – Confirm target engagement in living cells for more predictive results
Improved Hit Prioritization – More confidently Focus resources on the most promising chemical series
Potency Ranking
Potency ranking is essential in the lead optimization phase of drug discovery for selecting and refining compounds with strong target engagement.
CETSA measures how well a compound binds to its target in intact, biologically relevant cells, ensuring relevance to disease models. This helps establish a clear link between cellular target engagement and functional readouts, helping to establish a clear Structure-Activity Relationship (SAR) and ensuring that potency improvements translate into biological effects.
Key Benefits
- Biologically Relevant Potency Data – Measure target engagement in intact cells, ensuring potency rankings reflect real-world disease models.
- Stronger SAR Development – Establish a clear relationship between compound binding and functional biological effects.
- Reduced Late-Stage Attrition – Prioritize compounds with verified cellular target engagement to lower the risk of failures in later development stages.
Functional Assays
By combining cutting-edge technologies with expert assay development, we help demonstrate that compound binding translates into a measurable functional response—enabling more informed, data-driven decision-making throughout your drug discovery and development process.
Key Benefits
Informed Decision-Making – Strengthen confidence in target validation and guide compound optimization with actionable data.
Validated Biological Relevance – Establish a link between target engagement and functional cellular response.
Comprehensive Assay Solutions – Access both CETSA and traditional assays to assess target interaction and downstream effects.
Selectivity Profiling
Selectivity Profiling allows researchers to assess compound binding across individual proteins and entire biological pathways, offering insights beyond the limitations of conventional target panels. Given that many drug candidates interact with multiple physiological targets, our approach helps reveal off-target effects that traditional screening methods often miss.
Key Benefits
Flexible Service Options – Choose between fully customized profiling or a faster, standardized service in lysate.
Comprehensive Off-Target Detection – Unbiased, proteome-wide profiling reveals off-target interactions missed by conventional panels.
Enhanced Drug Safety and Efficacy – Ensure selective binding to the correct targets, minimizing potential liabilities early in development.