Linking Target Engagement to Biological Impact
Demonstrating that a compound’s interaction with its target leads to a meaningful biological effect reinforces the validity of the therapeutic approach and increases confidence in the target’s potential.
At Pelago Bioscience, our advanced infrastructure supports the development of robust CETSA® assays alongside traditional biochemical and cell-based assays. This integrated approach accurately assesses cellular target engagement and downstream biological effects.
By combining cutting-edge technologies with expert assay development, we help demonstrate that compound binding translates into a measurable functional response—enabling more informed, data-driven decision-making throughout your drug discovery and development process.
Key Benefits
- Validated Biological Relevance – Establish a link between target engagement and functional cellular response.
- Comprehensive Assay Solutions – Access both CETSA and traditional assays to assess target interaction and downstream effects.
- Informed Decision-Making – Strengthen confidence in target validation and guide compound optimization with actionable data.
How It Works
Our functional assay services are designed to provide clear, biologically relevant insights through a structured, science-driven approach:
- Assay Development – Customized development of CETSA®, biochemical, or cell-based assays to align with your specific target and pathway of interest.
- Target Engagement Analysis – Measurement of compound-target interactions in living cells using CETSA technology.
- Functional Response Evaluation – Assessment of downstream biological effects to confirm that target engagement leads to a meaningful cellular response.
Ready to validate the functional impact of your compounds?
Contact Us today to learn how our functional assay services can support your drug discovery strategy.
Get in touch
Contact us to learn more, to book a meeting or request a quote.