Confidently Advance Your Most Promising Compounds
Identifying initial hits is just the beginning. Before investing in optimization, it is crucial to confirm that these compounds bind to their intended targets in a physiologically relevant setting. This step ensures that resources are focused on the most viable candidates.
CETSA® offers direct, reliable evidence of target engagement within living cells, making it an ideal tool for hit confirmation across biophysical, biochemical, cell-based, or virtual screening hits. By validating compounds in a native cellular environment, CETSA® provides biologically meaningful insights and highly predicts downstream success.
At Pelago Bioscience, we offer comprehensive confirmatory testing and in-depth compound evaluation. Our approach helps refine the compound design and prioritize the strongest candidates, streamlining your hit confirmation process and accelerating the path to lead optimization.
Key Benefits
- Physiologically Relevant Validation – Confirm target engagement in living cells for more predictive results
- Improved Hit Prioritization – More confidently Focus resources on the most promising chemical series
- Streamlined Development Path – Accelerate progression to lead optimization by eliminating weak candidates early
How It Works
Our hit confirmation process integrates CETSA into a structured workflow to ensure reliable, actionable results:
- Assay Design and Validation – Tailored assay development to ensure robust, reproducible results specific to your target and compounds.
- Target Engagement Testing – Direct measurement of compound binding within a native cellular environment using CETSA.
- Data Analysis and Prioritization – In-depth evaluation of target engagement data to enable compound design and identify the most promising candidates for further development.
Ready to validate your hits with confidence?
Contact us today to discuss how our CETSA-powered hit confirmation services can support your drug discovery journey.
Get in touch
Contact us to learn more, to book a meeting or request a quote.