Elevating Early-Stage Drug Discovery
In drug discovery, primary screening is the critical first step in identifying compounds interacting with a specific target. Researchers can uncover potential drug candidates for further development by testing large compound libraries.
Leveraging CETSA® for primary screening ensures that only compounds demonstrating genuine cellular target engagement move forward. This significantly increases the chances of identifying high-quality drug candidates, minimizes false positives, and accelerates discovery.
Key Benefits
- True Target Engagement – Identify compounds with verified cellular target interaction.
- Fewer False Positives – Eliminate non-specific hits early to streamline follow-up efforts.
- Accelerated Discovery – Speed up your drug discovery process with efficient, high-throughput screening.
How It Works:
At Pelago Bioscience, our high-throughput screening (HTS) campaigns follow a structured, multi-phase approach—flexible and customizable to meet your project’s unique needs:
- Assay Development/HTS Adaptation – We optimize and validate assays to ensure they are robust, reproducible, and ready for large-scale screening.
- Pilot Screen – A small-scale run designed to assess assay performance and fine-tune screening parameters.
- Primary Screen – A comprehensive screening of your compound library to identify promising initial hits.
- Confirmation Assay – Rigorous re-validation of identified hits to confirm activity and eliminate false positives.
Find the Right Compounds, Right from the Start
Get faster, more reliable results with a primary screening strategy built around cellular data. Contact us today to learn how CETSA can help you uncover high-quality hits with confidence.
Get in touch
Contact us to learn more, to book a meeting or request a quote.