Bridging Preclinical Findings to Clinical Success
In drug discovery, translating preclinical findings into meaningful clinical outcomes is critical for reducing development risks, minimizing costly trial failures, and protecting patient safety. Confirming that a drug engages its intended target in controlled laboratory environments and complex biological systems, such as animal models and human-derived tissues is a significant challenge.
With Pelago Bioscience’s CETSA®-powered translational services, you can seamlessly extend your research from simplified systems to biologically relevant contexts. Our technology measures target engagement directly within cell lines, animal tissues, and human primary cells—providing a clear picture of how your compound performs in environments that better reflect real-world conditions. These insights help you make confident, evidence-based decisions, increasing the likelihood of clinical success and reducing the risks associated with trial failures.
Key Benefits
- Physiologically Relevant Validation – Confirm target engagement across cell lines, animal tissues, and human-derived systems for reliable translational insights.
- Reduced Development Risk—Validating efficacy in complex biological environments Strengthens confidence in your compound’s clinical potential.
- Streamlined Progression to Clinical Trials – Make informed, data-driven decisions that minimize costly trial failures and accelerate development timelines.
How It Works
Our translational services integrate CETSA technology into a streamlined workflow designed to ensure that preclinical insights remain valid in more complex systems:
- Preclinical Validation – Direct assessment of target engagement in cell-based systems to establish baseline efficacy.
- Cross-System Testing – Measurement of compound-target interactions in animal tissues and human primary cells for enhanced biological relevance.
- Data-Driven Analysis – Comprehensive interpretation of target engagement data to support decisions for clinical advancement.
Ready to bridge the gap between preclinical success and clinical relevance?
Contact Pelago Bioscience today to learn how our CETSA-powered translational services can help de-risk your drug development process.
