Our Services Within Target Discovery
Target Identification
Our CETSA® technology examines how compounds interact with the entire proteome in living cells. This unbiased, whole-proteome profiling gives a clear picture of both direct and off-target effects, as well as the cellular pathways responsible for driving disease, helping you make better, more informed drug discovery decisions from the very start.
Key benefits
- Proteome-Wide Insights: Get a complete view of how your compounds engage with proteins across the cell
- Early Off-Target Detection: Spot potential issues before they become costly problems
Pathway Discovery: Identify key cellular pathways influenced by your treatment
Assay Development
Unlike conventional target engagement assays, CETSA doesn’t require protein or ligand modifications, eliminating time-consuming assay development and molecular biology work, enabling a seamless translation from cells to more complex systems. This means faster setup times, fewer bottlenecks, and quicker access to meaningful data. What you see in cells, you will also see in patients.
What We Offer
- Rapid Assay Setup: Skip the complex probe development—get results faster without the need for cell or protein engineering
- Direct Target Engagement Readouts: Measure true interactions within living cells, without artificial modifications
- Tailored Assay Design: Customized solutions that adapt to your project’s unique goals and challenges
Expertise with Difficult Targets: Proven success developing assays for both well-established and hard-to-drug targets
Tool Evaluation
At Pelago Bioscience, we specialize in thorough, experimental validation of reference compounds. Our evaluation process confirms that previously reported effects hold under relevant biological conditions—helping you avoid false positives, minimize misleading data, and make more informed decisions as you move forward in your discovery journey.
Why Choose Our Tool Evaluation Service?
Stronger Hypothesis Building: Build a solid foundation for exploring target function in disease contexts
Experimental Validation: Confirm the biological relevance of your tool compounds through rigorous testing
Reduce Research Risk: Eliminate false positives and misleading data before advancing to lead generation
Pathway Analysis: Understand how validated compounds influence key biological pathways